The Cowgirls went 20-2 in 2012 and won their ninth straight American Southwest Conference title. HSU returns eight starters that started the NCAA playoff games last year.
Hardin-Simmons will open fall camp on Aug. 20 and will play host to Southwestern on Aug. 31 in the season opener.
Messiah was the preseason pick for No. 1 in the country, followed by William Smith, Johns Hopkins, Wheaton (Ill.), Trinity and Emory. HSU hosts No. 5 Trinity on Sept. 1 at HSU.