The Rambelles of Angelo State are ranked No. 1 in the region for the second straight week followed by Emporia State (Kan.) and Central Oklahoma, which is playing as an independent during 2012.
Missouri Western State leapfrogged the Wildcats into fourth place.
The Rambelles defeated the Wildcats Tuesday night at ASU's Softball Complex, 7-3, to win the season series, two games to one. Earlier in the week ACU split a doubleheader with ASU at home before taking two of three over the weekend from Eastern New Mexico.
The Wildcats will conclude their regular season this weekend at Midwestern State.
The rest of the poll includes No. 6 Southeastern Oklahoma, No. 7 Texas Woman's, No. 8 Tarleton State, No. 9 West Texas A&M, and No. 10 St. Mary's.
The top eight teams in the regional poll at the end of the regular season will be invited to the NCAA regional tournament. ACU's last trip to the regional tournament came in 2009.
1.) Angelo State
2.) Emporia State
3.) Central Oklahoma
4.) Missouri Western State
5.) Abilene Christian
6.) Southeastern Oklahoma
7.) Texas Woman's
8.) Tarleton State
9.) West Texas A&M
10.) St. Mary's (Texas)