Basal cell carcinoma is the form of skin cancer most commonly diagnosed in the United States. Even though it is slow-growing, it causes considerable morbidity and places a burden on health care systems.
Jiali Han, Ph.D., associate professor at Brigham and Women's Hospital, Harvard Medical School in Boston and Harvard School of Public Health was quoted as saying, "Our data indicates that the more caffeinated coffee you consume, the lower your risk of developing basal cell carcinoma."
"I would not recommend increasing your coffee intake based on this data alone," added Dr. Jiali Han. "However, our results add basal cell carcinoma to a list of conditions for which risk is decreased with increasing coffee consumption. This list includes conditions with serious negative health consequences such as type two Diabetes and Parkinson's disease."
Han and his colleagues generated their results by conducting a prospective analysis of data from the Nurses' Health Study, a large and long-running study to aid in the investigation of factors influencing women's health, and the Health Professionals Follow-up Study, an analogous study for men.
Of the 112,897 participants included in the analyses, 22,786 developed basal cell carcinoma during the more than 20 years of follow-up in the two studies. There were different results in participants who consumed coffee or other dietary sources of caffeine such as chocolate, tea, or cola. These individuals did not develop basal cell carcinoma.
"These results really suggest that it is the caffeine in coffee that is responsible for the decreased risk of basal cell carcinoma associated with increasing coffee consumption. This would be consistent with published mouse data, which indicate caffeine can block skin tumor formation. However, more studies in different population cohorts and additional mechanistic studies will be needed before we can say this definitively," Dr. Han explained.
In contrast to the findings for basal cell carcinoma, neither coffee consumption nor caffeine intake were inversely associated with the two other forms of skin cancer, squamous cell carcinoma and melanoma, the most deadly form of the disease.
"It is possible that these numbers are insufficient for any association with coffee consumption to be seen. As the study participants are followed for a longer time, the number of cases of these conditions is likely to increase. We may be in a position in 10 years' time to better address this issue," Dr. Han concluded.