The accident happened around 8:20 p.m. Saturday.
According to police on scene, an SUV heading northbound on Treadaway Blvd. was turning onto Butternut St. and struck a motorcycle with two passengers.
Both were transported to Hendrick Medical Center with life-threatening injuries.
The driver of the SUV and the two young children inside were unharmed, police said.
Names of those involved have not been released at this point.