The home was on a county road in the middle of cotton field, about one mile from I-20.
It took 35 firefighters to combat the flames and they were able to get it under control in about an hour and a half.
No clue at this point as to what caused the fire.
The house is destroyed, but the 11,13, and 17-year-old, as well as their parents got out safely.
The Colorado City Fire Department is currently accepting donations for the family.