The deadly accident happened just before 12:30 p.m. near the 3400 block of West Stamford St. in the area where I-20 and the Winters Freeway merge.
According to Abilene Police, a maroon Ford Explorer was heading eastbound on I-20 when it crashed into a white Nissan Quest that was merging onto the Interstate from the Winters Freeway.
The Explorer went off the road and flipped; the driver, 43-year-old Marlinda Beasley was thrown from the vehicle and killed instantly, police said.
No one in the Nissan suffered injuries.
At this point, police believe wet roads may have played a factor in the crash.
Officers said Beasley was not wearing a seatbelt at the time.
The investigation continues.